The Possible Effects of Asiatic Herbs in SARS-COV-2 and their Mechanism of Action

In 2019, a new virus called Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) gave rise to an unknown outbreak that spread in China’s Hubei province, triggering epidemic known as coronavirus-19 (COVID -19). Several studies have demonstrated the metabolic pathways of SARS-COV-2 angiotensin-converting enzyme receptors (ACE2). With this, others been considering approach with drugs bind ACE2 well antiviral activity possible treatment option for disease. Thus, objective this present review was evaluate some Asiatic herbs both prevention and COVID-19. Some herbs, such extract Artemisia annua (Artemisinins) Isatis indigotica (Emodin), showed be effective inhibitors adhesion viruses. observed SARS-CoV S / ACE -2 protein interaction which it inhibited cell surface. Similarly, Glycyrrhiza glabra (Licorice) significant inhibiting action on influenza shown many other viruses by weakening activity, gene expression replication, reducing force stress through reduction high-mobility-group box1 (HMGB1) binding DNA. Additionally, one best concentration value (EC50) found study Lycoris Radiata EC50: 2,4 ± 0.2 μg ml. The results presented are promising search prophylactic viral pandemic SARS-VOC-2. However, more clinical trials validate processes effectiveness plants their extracts, synergy between themselves needed future herbal treatments against